| ncRNA name | hsa-miR-320 |
| ncRNA Category | miRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | normal retinas, RB samples; RB cell line Y79, WERI‑RB‑1 and SO‑RB50; human embryonic kidney cell line HEK293 |
| Methods | qRT-PCR, transwell assay, Western blot, luciferase reporter assay |
| Expression pattern | down-regulated |
| Functional description | Overexpression of miR-320 was demonstrated to inhibit proliferation, migration and invasion of RB cells.Luciferase reporter assay confirmed that the SP1 3'-untranslated region contains a direct binding site for miR-320, and restoration of miR-320 expression decreased the mRNA and protein expression levels of SP1. |
| PubMed ID | 28627594 |
| Year | 2017 |
| Title | MicroRNA-320 inhibits cell proliferation, migration and invasion in retinoblastoma by targeting specificity protein 1. |
| Drug-related ncRNA | NO |
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